Synthesis, characterization and biological evaluation of Schiff’s bases derivatives as potent antibacterial agents

Versha Parcha, Ankit Kumar, Babita Mahajan, Jaswinder Kaur


Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential.

Methods: Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect against Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus& Bacillus cereus.

Results: From this study it could be observed that schiff’s bases 2-[( aminophenylhydrazinyldene o,m,dinitrobenzoyl] aniline (H) and compound 2-[( aminophenylzinyldene) p amino benzoyl] aniline (I) showed very good zone of inhibition against almost all strains tested for.

Conclusions: So further attempts could be made to extend the series and explore their antibacterial potential to achieve hopeful goal.


Antimicrobial, Schiff’s base, Shigella sonnei

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Duan LP, Wen AD, Wu NB, TaoY, Zhang HB. Synthesis and anti-intestinal nematode activity of variously substituted benzo-naphthyridine derivatives. Molecules 2011;16:1593–602.

Dhar DN, Taploo CL. Schiff bases and their applications. J Sci Ind Res. 1982;41:501–6.

Gurupadayya BM, Gopal M, Padamshali, Manohara YN. Synthesis and pharmaceutical evaluation of azetidine-2-ones and thiazolidine-4-ones encompassing benzo-thiazole. Indian J Pharm Sci. 2008;70:572–7.

Hearn MJ, Cynamon MH, Chen MF, Coppins R. Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid. Eur J Med Chem. 2009;44:4169-78.

Aboul-Fadl T, Bin-Jubair FAS, Aboul-Wafa, O. Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building. Eur J Med Chem. 2010;45:4578-86.

Kumar KS, Ganguly S, Veerasamy R, De Clercq E. Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones. Eur J Med Chem. 2010;45:5474-9.

Firke SD, Firake BM, Chaudhari RY, Patil VR. Synthetic and pharmacological evaluation of some pyridine containing thia-zolidinones. Asian J Res Chem. 2009;2:157–61.

Sharma MC, Sahu NK, Kohli DV, Chaturvedi SC, Sharma S. Synthesis, characterization and biological activities of some 1-(nicotinylamino-2-substituted azetidine-4-ones as potential antibacterial agents. Dig J Nanomater Bios. 2009;4:361-7.

Varshney MM, Husain, A, Parcha V. Synthesis, characterization and biological evaluations of 2-(4- hydroxyaryl)–N’-({5’-(substituted aryl)-furan-2’-yl}-methylidene)-ketohydrazides Schiff bases. Der Pharma Chemica, 2014;6:241-7.

Jesmin M, Ali MM, Habib MR, Khanam JA. Antimicrobial activity of some Schiff bases derived from benzoin, salicylaldehyde, aminophenol and 2,4 dinitrophenyl hydrazine. Mycobiology. 2008;36:70–3.

Siddique M, Saeed AB, Dogar NA, Ahmad S. Biological potential of synthetic hydrazide based Schiff bases. J Sci Innov Res. 2013;2:651-7.

Collins AH. Microbiological Methods, 2nd. ed;1976. Arnold, Hodder Headline Group, 338 Euston Road, London NW1 3BH ISBN 0 340 80896 9.

Cruickshank R, Duguid JP, Marion BP, Swain RHA. Medicinal Microbiology.12th. ed; 1975: 196-202.

Varshney MM, Husain, A, Parcha V Synthesis and characterization of 5-(substitutedphenyl)-2-furfuraldehydes from substituted anilines. World J Pharmacy Pharm Sci. 2015;2(4):1802-6.



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