Mucoadhesive drug delivery system: an overview

Parijat Pandey, Manisha Saini, Neeta .


The major objective of any dosage form is to deliver an optimum therapeutic amount of active agent to the proper site in the body to attain constant & maintenance of the desired drug concentration. Mucoadhesive drug delivery systems are effective delivery systems with various advantages as compared to other oral controlled release dosage forms in terms of drug delivery at specific sites with prolonged retention time of drugs at target sites. The main advantage of these systems includes avoiding first pass metabolism of the drugs and hence availability of high drug concentration at target site. Oral mucoadhesive systems have potential ability for controlled and extended release profile so as to get better performance and patient compliance. The present manuscript briefly reviews the benefits of mucoadhesive drug delivery systems, mechanisms involved in mucoadhesion, different factors affecting mucoadhesive drug delivery systems.


Oral route, Mucoadhesive drug delivery system, Bioavailability

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Gawas SM, Dev A, Deshmukh G, Rathod S. Current approaches in buccal drug delivery system. Pharm Biol Eval. 2016;3(2):165-77.

Nagpal N, Bajaj J, Saini G, Kaur L, Sharma K, Arora M. Mucoadhesion: A new polymeric approach. Bull Pharm Res. 2016;6(3):74-82.

Carvalho FC, Bruschi ML, Evangelista RC, GremiĆ£o MPD. Mucoadhesive drug delivery systems. Braz J Pharm Sci. 2010;46(1):1-17.

Khan AB, Mahamana R, Pal E. Review on mucoadhesive drug delivery system:Novel approaches in modern era. J Pharm Sci. 2014;4 (4):128-41.

Muraleedhara KK, Kumar SKS, Parthiban S. Mucoadhesive vaginal drug delivery system:A review on advance status. Int J Pharm Res Anal. 2013;3(1):33-46.

Mathew AK. Oral local drug delivery: An overview. Pharm Pharmacol Res. 2015;3(1):1-6.

Gandhi SD, Pandya PR, Umbarkar R, Tambawala T, Shah MA. Mucoadhesive Drug Delivery Systems-An Unusual maneuver for site specific drug delivery system. Int J Pharm Sci. 2011;2(3):132-52.

Khanderao RJ, Pawar AY, Gokul ST. Bioadhesive drug delivery system: An overview. Asian J Pharm Clin Res. 2013;6(2):1-10.

Dharmendra S, Surendra JK, Sujata M, Ashish P, Shweta S. Mucoadhesive drug delivery system: A review. Int J Pharm Biol Arch. 2012;3(6):1287-91.

Alexander A, Sharma S, Ajazuddin, Khan MJ, Swarna. Theories and factors affecting mucoadhesive drug delivery systems: A review. Int J Res Ayur Pharm. 2011;2(4):1155-61.

Tangri P, Khurana S, Madhav S. Mucoadhesive dru gdelivery: Mechanism and methods of evaluation. Int J Pharma Bio Sci. 2011;2(1):458-67.

Muthukumaran M, Dhachinamoorthi D, Chandra SKB, Sriram N. A review on polymers used in mucoadhesive drug delivery system. Int J Pharm Ind Res. 2011;1(2):122-7.

Khan S, Verma M, Aggarwal G, Kumar SLH. Mucoadhesive drug delivery system:A review. World J Pharma Pharm Sci. 2016;5(5):392-405.

Singh R, Sharma D, Garg R. Review on mucoadhesive drug delivery system with special emphasis on buccal route: an important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals. J Dev Drugs. 2017;6(1):1-12.

Shaikh TH, Shinkar DM, Saudagar RB. Review: Polymers Used in the Mucoadhesive Drug Delivery System. Int J Pharma Res Rev. 2016;5(5):45-53.

Saini G, Bajaj J, Dhawan R, Rahar S, Arora M, Nagpal N. Evaluation parameters of mucoadhesive drug delivery system. Int J Pharm Life Sci. 2016;7(5):5080-8.

Mathew AK. Oral local drug delivery:An overview. Pharma Pharmacol Res. 2015;3(1):1-6.

Mahajan P, Kaur A, Aggarwal G, Harikumar SL. Mucoadhesive drug delivery system:A review. Int J Drug Dev Res. 2013;5(1):11-20.

Yadav VK, Gupta AB, Kumar R, Yadav JS, Kumar B. Mucoadhesive polymers:Means of improving the mucoadhesive properties of drug delivery system. J Chem Pharm Res. 2010;2(5):418-32.

Roy SK, Prabhakar B. Bioadhesive polymeric platforms for transmucosal drug delivery systems - A review. Trop J Pharm Res. 2010;9(1):91-104.

Hooda R, Tripathi M, Kapoor K. A review on oral mucosal drug delivery system. Pharma Innov. 2012;1(1):1-14.



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