Possible interactions between garlic and conventional drugs: a review

Mital B. Kansara, Ashutosh J. Jani


Herbs can affect body function; therefore, when herbs are taken concurrently with drugs, interactions are possible. The interaction between drugs and herbal medicines is a safe concern and these interactions are especially important for drugs with narrow therapeutics index. The probability of herb-drug interaction can be higher than drug interaction, if conventional drug having single chemical entities, whereas most of the herbal medicinal product contain a mixture of pharmacologically active constituents. The herb-drug interaction may involve either an increase or decrease in the amount of drug in blood, either by altering the absorption, distribution, metabolism, and elimination (ADME) of drug and by antagonizing or synergism of the effect of drug or pharmacodynamics interaction may arise. This article we focus on how garlic interacts with conventional drug or it is favourable or not.


Herbal-drug interaction, Pharmacokinetic, Pharmacodynamics, Garlic, Interaction with the conventional drug

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Gul D. Herbal drugs and drug interactions. Marmara Pharmaceutical Journal. 2012;16:9.

Bent S, Ko R. A review Commonly used herbal medicines in the United States. Am J Med. 2004;116:478-85.

Ismail M Y. Herb-drug interactions and patient counselling. International journal of pharmacy and Pharmaceutical Sciences. 2009;1:151.

Graham RE, Gandhi TK, Borus J, Seger AC, Burdick E, Bates DW, et al. Risk of concurrent use of prescription drugs with herbal and dietary supplements in ambulatory care. In: Advances in Patient Safety: New Directions and Alternative Approaches. 2008;4:1.

Mohamed-Eslam FM, Frye RF. Effect of herbal supplements on drug glukuronidation. Review of clinical, animal, and iv vitro studies. Planta Med. 2011;77:311-21.

Dr. Huda K .Possibility of potential herbal-drug interactions in elderly population. The Journal of Phytopharmacology. 2016;5(3):128.

Fugh-Berman A, Ernst E. Herb–drug interactions: Review and assessment of report reliability. Br J Clin Pharmacol. 2001;52(5):587–95.

Skalli S, Zaid A, Soulaymani R. Drug interactions with herbal medicines. Therapeutic drug monitoring. 2007;29(6):679-86.

Dharmananda S. Checking for possible Herb-drug Interactions. ITM 2003.

Kafeel H, Rukh R, Qamar H, Bawany J, Jamshed M, Sheikh R et al. Possibility of Drug-Drug Interaction in Prescription Dispensed by Community and Hospital Pharmacy. Pharmacology & Pharmacy. 2014;5:401-07.

Mamindla S, Prasad KVSRG, Koganti B. herb-drug interactions: an overview of mechanisms and clinical aspects. International journal of pharmaceutical sciences and research. 2016;1:1.

Sharma AB. Global medicinal plants demand may touch $5 trillion by 2050. Indian Express. 2010.

Colalto C. Herbal interactions on absorption of drugs: mechanisms of action and clinical risk. Pharmacol Res. 2010;62:207-27.

Vermaak I, Hamman JH, Viljoen AM. High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products. SA J Bot. 2010;76:119-24.

Lin JH, Lu AYH. Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet. 1998;35:361-90.

Tope SA, Sunday OF, Gabriel AT. Mechanisms of antiulcerogenic effect of garlic (Allium sativum) in albino rats. Int J Trop Med. 2013;8(5):119-23.

Rivlin RS. Is garlic alternative medicine? J Nutr. 2006;136:713-15.

El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. Gastroprotective Effect of Garlic in Indomethacin Induced Gastric Ulcer in Rats. Nutrition. 2016:5.

Qidwai W and Ashfaq T. Role of garlic usage in cardiovascular disease prevention: an evidence-based approach. Evid Based Complement Alternat Med. 2013:1.

Mikaili P, Maadirad S, Moloudizargari M, Aghajanshakeri S, Sarahroodi S. Therapeutic Uses and Pharmacological Properties of Garlic, Shallot, and Their Biologically Active Compounds. Iranian Journal of Basic Medical Sciences. 2013;16:1031.

Rajasekaran R, Kuan-Hung L, and Lee-Yan S. Recent Research Progress on Garlic as a Potential Anticarcinogenic Agent Against Major Digestive Cancers. Journal of traditional and complimentary medicine. 2012;2:192-201.

Azene T, Work M. Traditional Uses, Phytochemistry and Pharmacological Properties of Garlic (Allium Sativum) and its Biological Active Compounds. 2015;5:142-48.

Swadesh: health­wealth:benefits of garlic. Available at https://meradeshswadesh.blog spot.in/2013/10/health­wealthbenefits­of­garlic.html. Accessed on 13 March 2017.

Izzo AA. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data. ed Princ Pract. 2012;21:405.

Naveen P, Gopi Shankar B, Srikanth V, Laxmaiah Ch, Prathapani S. A review: herb-drug interactions” indo american journal of pharmaceutical research. 2011;1:367-72.

Wojcikowski K, Wohlmuth H, Johnson DW, Rolfe M, Gobe G. An in vitro investigation of herbs traditionally used for kidney and urinary system disorders: potential therapeutic and toxic effects. Nephrology (Carlton). 2009;14:1.

Kuruvilla M, Gurk-turner C. A review of warfarin dosing and monitoring. Bumc. 2001;14:305–06.

Heck AM, Dewitt BA, Lukes AL. Potential Interactions Between Alternative Therapies and Warfarin. American Journal of Health-System Pharmacy. 2000;57:13.

British Hypertension society beta-adrenoceptor antagonists available from: g:websitedrug classesdrug classes final copy Dec 2008beta-adrenoceptor antagonists.doc Accessed on 5 January 2017.

Avula PR, Asdaq SM, Asad M. Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats. Indian J Pharmacol. 2014;46:94-9.

Prichard BNC. Propranolol and /-adrenergic receptor blocking drugs in the treatment of hypertension. Br J Clin pharmac. 1982;13:51-60.

Asdaq SMB, Inamdar MN, et. Interaction of propranolol with garlic in Biochemical and Histological Changes in rat, Iranian Journal of Pharmaceutical Research. 2009,8(3):201-07.

British hypertension society calcium channel blockers available from: g:websitedrug classesdrug classes final copy dec 2008calcium channel blockers.doc. Accessed on 10 January 2017.

Adhikari A, Indu R, Sur TK , Banerjee D, Das AK. Is Garlic a Safe Remedy: An Overlook Herb Drug Interaction? American Journal of Phytomedicine and Clinical Therapeutics. 2015:622-32.

Wang Y, Zou M, Zhao N, Ren J, Zhou H, Cheng G. Effect of diallyl trisulfide on the pharmacokinetics of nifedipine in rats. J Food Sci. 2011;76:30-4.

British hypertension society angiotensin converting enzyme (ace) inhibitors available form: g:websitedrug classesdrug classes final copy dec 2008angiotensin converting enzyme.doc. Accessed on 14 January 2017.

Asdaq SMB, Inamdar MN. Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril, Phytomedicine. 2010;17:1016–26.

Duarte JD, Cooper-DeHof RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretic. 2010;8:7.

Asdaq SM, Inamdar MN. The potential for interaction of hydrochlorothiazide with garlic in rats. Chem Biol Interact. 2009;181: 472–79.

Endo A. The discovery and development of HMG-CoA reductase inhibitors. J. Lipid Res. 1992;11:1569–82.

Reddy DG, Reddy GA, Rao SG, Haritha C, Jyothi k. Interaction on study on garlic and Atorvastatin with reference to Nephrotoxicity in Dyslipidaemic Rats. 2010;17:90-3.

Stephen C. Piscitelli, Burstein A H, Nada W, Keith D. Gallicano Falloon J. The Effect of Garlic Supplements on the Pharmacokinetics of Saquinavir. 2002;34:234-38.

Piscitelli SC, Burstein AH, Welden N, et al. Effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis. 2002;34:234­8.

Kraus LA ,Samuel SK, Schmid SM, Dykes DJ, Waud WR, Bissery MC. The mechanism of action of docetaxel Taxotere in xenoraft models is not limited to bcl phosphorylation. 2003;21:259–68.

Frenkel M, Gupta A. Nutritional Supplements and Docetaxel: Avoid or Combine? Journal of the Society for Integrative Oncology. 2010;8:120-25.

Luzi L,Pozza G.Glibenclamide: an old drug with a novel mechanism of action?PubMed ­ NCBI. 1997;4:239­44.

Poonam T, Prakash GP, Kumar LV. Influence of Allium sativum extract on the hypoglycemic activity of glibenclamide: an approach to possible herb-drug interaction. Drug Metabol Drug Interact. 2013;28:225-30.

Timmins GS, Dereti V. Mechanisms of action of isoniazid. Molecular Microbiology 2006;62:1220–27.

Dhamija P, Malhotra S, Pandhi P. Effect of oral administration of crude aqueous extract of garlic on pharmacokinetic parameter of isoniazid and rifampicin in rabbits. Pharmacol. 2006;77:100-10.

Graham GG, Cott K, Mechsiam of action of paracetamol . Am J Ther. 2005;12:46-55.

Angelo A. Izzo. Herb–drug interactions: an overview of the clinical evidence. Fundamental & Clinical Pharmacology. 2004;19:1–16.

Satoshi M, Shigeo K. Mechanisms of action of cyclosporine. Immunopharmacology. 2000;47:119–25.

Garlic medicine health. Available from http://www.emedicinehealth.com/garlic-page3/vitamins-supplements.htm Accessed on 10 January 2017.

Liu YC, Lo YK, Wu SN. Stimulatory effects of chlorzoxazone, acentrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH cells. Brain Research. 2003;959:86–97.

Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui Y, et al. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John’s wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging. 2005; 22:525-39.

DOI: http://dx.doi.org/10.26510/2394-0859.pbe.2017.12


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